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Getting Started with Silverstone Matchmaker

This guide is intended as a tool for learning the basics of Matchmaker. By performing simple procedures using the sample data provided, you will gain a foundation for using Matchmaker throughout the lifecycle of the PKD process. The guide also provides some reference material, such as the required formatting of a data file for import into Matchmaker.


Matchmaker software is a clinical application that allows doctors and hospitals to match paired kidney donors and recipients more quickly and reliably than ever before. Using proprietary algorithms, powerful optimization methods, and up to 14-antigen matching, more living donor transplants can be performed with highly predictive cross-match compatibility for groups containing hundreds of recipients...

Installing Matchmaker

This section helps you install Matchmaker and get it running.

Importing Data

This section helps you import a properly formatted data file into Matchmaker so you can perform all the procedures contained in this guide. You'll use a sample file that comes with the product so you can get started right away.

Using Matchmaker

In this section, you will take a pool of unmatched donors and recipients and generate highly qualified match lists based on the criteria you set. This section takes you from start to finish using realistic data and gives you a great sense of the overall process of using Matchmaker.

Appendix A: Formats

Matchmaker Feature Guide


Silverstone Matchmaker was created to move organ recipients off the waiting list; off dialysis and, ultimately, to help save lives. The critical shortage of living organ transplants is dramatically improved through the use of Matchmaker by providing doctors and clinicians the ability to rapidly and accurately build sophisticated cross-matching tables for paired donations from a varying set of recipient and donor clinical records. These cross-matching tables enable transplant professionals to rapidly find and analyze potential organ donations by mixing and matching a varying pool of potential donors with recipients in order to provide the best possible placement of compatible organs with recipients that are in need.

Developed with the diverse needs of clinics in mind, Matchmaker seeks to present all relevant cross-matching data analysis in a general purpose way so that it can be easily integrated into the transplant work-flow regardless of the infrastructure implemented by the clinic. As the major feature areas of Matchmaker are explored below, it should be apparent how this leading-edge product addresses many of the myriad problems encountered by any clinic interested in expanding into a full-service, paired donation program. Matchmaker will serve as a highly valuable addition by helping to address the serious needs that face the tens-of-thousands of organ transplant candidates currently on the wait list.

Intuitive Tabbed Interface

All necessary data analysis and views are presented in a single, easy to understand, tabbed user interface. This approach greatly eases access to the most important data analysis including the innovative “Matchmaker” startup tab – an all inclusive statistical view of current match status. MORE...

Simple Data Import, Export, and Updating

Data import and export is simplified by relying on the industry standard .csv file format. This strategy accommodates the vast array of clinical IT processes and assists in removing potential errors in data transcription. MORE...

Optimized and Redundant Methods of Matching

Data quality, speed, and accuracy are assured through the inventive implementation of two custom match algorithms. This approach combines two match algorithms to deliver a wide range of matching capabilities., including two-way, three-way, and virtual cross-matching. MORE...

Unique Methods of Data Visualization and Reporting

Several efficient mechanisms for studying and evaluating large amounts of clinical data are provided, including some novel methods for visually analyzing and reporting discreet recipient/donor data. MORE...

Novel “Pair ID” and “Case Management” Features

Provides a drill-down capability that presents a more concise method for reviewing targeted pair information on a recipient-by-recipient basis. On-the-fly “snapshot” HTML files can be archived to maintain an audit trail of decisions for historical review. MORE...

Commercial-grade Software built for Nephrologists

Enterprise-ready software created by software professionals based on extensive feedback from practicing nephrologists and through direct personal experience. MORE...

Matchmaker FAQ

What is Matchmaker?

Matchmaker is an expert system application that aides doctors and clinicians in managing the paired donation program process.

How does Matchmaker work?

Using a series of proprietary algorithms, Matchmaker checks for ABO compatibility and HLA antigen information across a pool of donors and recipients. It then generates a list of all of the possible paired matches for every patient and recipient in the pool. It then optimizes that information to determine the most and best possible matches. Matchmaker gives doctors the flexibility to look at all possible options that were previously unavailable to them.

What is paired donation?

Paired donation allows transplant patients with willing but incompatible donors the option for their donor to donate to a pool but not directly to them, and for the recipient to then find a match within the pool. A paired donation program is essentially a pool of incompatible donor/recipient pairs who are willing to donate, but simply incompatible. Paired donation gives people with end-stage renal disease another viable option for a kidney transplant.

What is the difference between a paired donation and deceased organ donation?

Deceased donor organs are managed by UNOS. Transplant entered into the deceased donor pool when your kidney fails and there is no way of knowing how long it will take. Typical wait times for Type O peoloe is five years and growing. It also depends upon where you live in the nation. Paired donation uses a living donor and can quite often get you matched up more rapidly. Paired donation is an elective surgical option that depends upon your donor/recipient blood type mix.

Is living, paired donation better than being on the deceased donor list?

Yes, living, paired donation is better than deceased organ donation. Living donation, whether the donor is related or unrelated to the recipient, has much higher success rates in both the short and long term. Find the right percentage. Percentages are specific to hospitals, however national averages (get it off the Web site).

Does Matchmaker only find matches for patients in need of kidneys?

Yes, Matchmaker is specialized to identify kidney matches only. If I’m a doctor, how do I buy Matchmaker? Send an email to for licensing information.

How can I join a paired donation program?

There are a number of paired donation programs throughout the United States. We recommend you talk to your nephrologists and/or transplant hospital to find out if whether they have a program and, if they do, how you can join.

If I’m a patient, how much does it cost me to be part of a paired donation program?

Contact your transplant hospital to find out the cost of joining its paired donation program. Costs vary based on your hospital and insurance plans.

How long does it take Matchmaker to find a match?

The length of time it takes to find a match varies. Matches are based on your particular immunological status and that of other people in the pool, as well as the number of people in the pool. In general, Matchmaker can make a match for 30% of the pool.

I have a degenerative kidney disease although my kidney hasn’t failed yet. Can I participated in a paired donation program?

Consult with your nephrologist or transplant hospital to find out about whether or not they offer early registration At Silverstone, we believe that early registration in a paired donation program will increase your options for find a match in a more timely manner.

Advantages of Paired Donation

  • Deceases time on deceased donor organ wait list
  • Decreases time on dialysis
  • Decreases healthcare costs significantly
  • Increases healthy organ procurement
  • Increases short and long-term success rates


Today, there are over 70,0001 people on the kidney transplant list waiting for a deceased donor organ. The average wait time for a kidney is three to six years depending upon blood type, region and other factors. Many of these transplant candidates will die before they receive an organ, and the transplant list continues to grow at an alarming rate-- almost 10% annually for the past decade.2 The financial resources required to care for these patients places an enormous burden on an already overtaxed medical system. Additionally, the longer a transplant candidate remains on the list, the longer they remain on dialysis, which significantly increases the likelihood of developing morbid disorders associated with prolonged dialysis and raises the cost of care astronomically for each patient.

Paired Donation

A New Approach

Paired donation is an innovative approach that utilizes healthy, living donor organs when the intended recipient is incompatible with his or her donor. The basic process is to match two incompatible donor/recipient pairs with an alternate compatible pair.

By increasing the availability of viable living donor organs, more people can be transplanted, lessening the impact on the deceased donor organ waiting list and allowing end stage renal disease patients the opportunity to have a living donor from a less restrictive pool of organs. Additionally, research shows that living donor kidneys are preferable to deceased donor kidneys. The latest five-year graft survival rate for deceased donor kidney transplants is 66.7%, while the rate for living donor transplants is 80.2%.3

The notion of paired donation has been pioneered at a number of institutions, most notably the Johns Hopkins University Incompatible Kidney Transplant Program, who performed the first paired donation kidney transplant in the United States in 2001. However, despite all its obvious and important advantages, relatively few paired donations have been performed nationally.4

Barriers to Paired Donation

The biggest hurdle to paired donation is the painstaking process of combing through all the recipient/donor data and finding a match. This requires the ability to analyze in real time a potential incompatible donor pair with all other pairs in the pool in real time while evaluatiing their blood types, antigen avoids, age differentials and more. When one multiplies the time and cost required to complete this analysis for every incompatible pair on the list, it‘s no surprise why so few successful paired donation transplants have occurred.

The Matchmaker Solution

Silverstone Solutions has developed a solution for this problem, Matchmaker, a clinical application designed with advice from leading nephrologists, that utilizes a suite of custom algorithms to generate paired donation matches for an entire pool of potential recipients. Matchmaker can perform the difficult task of co-matching two interested donor/recipient pairs from a selectable pool of alternative donor-recipient pairs. It also evaluates key immunologic parameters including blood type, 14 specific antigens, age and degree of compatibility with other donor-recipient pairs on the list. Finally, it optimizes the pairings to yield the greatest number of transplants for a given pool. Matchmaker can provide results in minutes that would not be possible by hand. Matchmaker is also a robust and flexible tool that allows nephrologists and transplant clinics to directly manipulate the pairs to their exact requirements. Triple swaps are also readily analyzed. For more information about our products, please review our Product Overview page.

  1. Source: United Network for Organ Sharing, January 2007
  2. Source: OPTN/SRTR as of May 2, 2005
  3. Source: 2005 OPTN/SRTR Annual Report, Table 1.13.
  4. As of April 25, 2005 – Johns Hopkins transplanted 51 patients via paired donor exchanges, the most of any organization in the country.

Copyright © 2007 SilverstoneSolutions Inc. All rights reserved.

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